NSA Spied On European Union States At Brussels And UN, Der Spiegel Says Edward Snowden Documnets Show

Der Spiegel cited from a September 2010 "top secret" National Security Agency document that it said the fugitive former NSA contractor had taken with him to Hong Kong and which its journalists had seen in part, Reuters reported.

The document outlines how the NSA bugged offices and spied on EU internal computer networks in Washington and at the United Nations, not only listening to conversations and phone calls but also gaining access to documents and emails. The document explicitly called the EU a "target."

The revelation is the latest in a cascade of disclosures set off by Snowden's flight.

According to Der Spiegel, the NSA also targeted telecommunications at the Justus Lipsius building in Brussels, home to the European Council that groups EU national governments, by using a remote maintenance unit.

Without citing sources, the magazine reported that more than five years ago security officers at the EU had noticed and traced several missed calls to NSA offices within the NATO compound in Brussels.

Each EU member state has rooms in Justus Lipsius with phone and Internet connections, which ministers can use.

The spying methods resemble those reportedly?used by the British at the 2009 G20 Summit in London, which saw the UK's Government Communications Headquarters into phones and computers used by heads of state. That surveillance campaign was uncovered by a separate Snowden leak earlier this month.

Snowden fled from Hawaii to Hong Kong in May, a few weeks before publication in the Guardian and the Washington Post of details he provided about secret U.S. government surveillance of Internet and phone traffic. He has been holed up in a Moscow airport transit area since last weekend.

To contact the editor, e-mail:

Source: http://au.ibtimes.com/articles/484721/20130630/nsa-edward-snowden-der-spiegel-nsa-surveillance-us-spying-on-europe-us-spying-on-allies-nsa-leaks.htm

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Golf-In-form Dutchman Luiten leads Irish Open

June 29 | Sat Jun 29, 2013 5:30pm BST

June 29 (Reuters) - Dutchman Joost Luiten will be chasing his second European tour victory of the month when he takes a one-shot lead into the final round of the Irish Open on Sunday.

The world number 94, who won the Austrian Open three weeks ago, hit a six-under par 66 in the third round on Saturday to lead Spain's Pablo Larrazabal by one shot at Carton House, County Kildare.

Overnight joint-leader Robert Rock is third, three shots behind Luiten, who also finished tied for 10th at the BMW International Open in Munich and 11th at an event in Sweden this month.

"It was good today - a round in this wind with no bogeys is always good," the 27-year-old told the European tour website (www.europeantour.com).

"It looks like I'm playing good, playing consistently. I don't make a lot of silly mistakes, the game feels good."

Luiten made six birdies in his round of 66, a score matched by Larrazabal and England's Rock was steady on his way to a one-under-par 71.

England's Paul Casey, a former world number three and European Ryder Cup player, finished a shot behind Rock after a third-round 67.

A number of leading players, including Northern Ireland's world number two Rory McIlroy, missed the cut just three weeks before the British Open starting at Muirfield, Scotland on July 18. (Reporting by Josh Reich, editing by Ed Osmond)

Source: http://feeds.reuters.com/~r/reuters/UKGolfNews/~3/5SiMb27mn88/golf-european-idUKL3N0F507Y20130629

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NATO convoy attacked by suicide bomber

KABUL, Afghanistan (AP) ? Authorities say two civilians were killed when a suicide bomber attacked a convoy of NATO-led coalition troops in western Afghanistan.

Farah provincial governor spokesman Abdul Rahman Zhawandi said Saturday a man and woman on a motorcycle riding near the convoy were killed when the suicide attacker struck Thursday evening. Five civilians were wounded.

Coalition forces spokesman Capt. Luca Carniel says no NATO forces were hurt in the attack, but did provide medical assistance to the wounded civilians.

Elsewhere, in the central Oruzgan province, police spokesman Fareed Ayal said 20 Taliban fighters and one police officer were killed in an operation late Thursday.

Though the Taliban have indicated they are willing to start peace talks at a new office in Qatar, they have not renounced violence and attacks remain regular.

Source: http://news.yahoo.com/nato-convoy-attacked-suicide-bomber-084353465.html

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Senegalese president defends anti-gay law

DAKAR, Senegal (AP) ? Senegalese President Macky Sall has defended his refusal to decriminalize homosexuality one day after publicly clashing with President Barack Obama on the issue at a joint press conference.

In an interview with The Associated Press, Sall said it was important for other countries to refrain from imposing their values beyond their borders. He compared his position on homosexuality to other countries' positions on polygamy, which is widely practiced in Senegal.

"We don't ask the Europeans to be polygamists," Sall said. "We like polygamy in our country, but we can't impose it in yours. Because the people won't understand it, they won't accept it. It's the same thing."

Senegal's penal code calls for prison sentences of up to five years and fines of up to $3,000 for committing "an improper or unnatural act with a person of the same sex."

Despite the law, Sall maintained that gays were not persecuted in Senegal, and were prosecuted only if they violated the law. He also said the population, while opposed to homosexuality, was not actively intolerant.

"I think in Senegal people are very quiet. They are not very violent, even for the homosexuals," he said.

Local activists strongly disagree, pointing out that more than a dozen homosexuals are currently in jail for no other reason than their sexual orientation, with guilty verdicts having been handed down despite a lack of evidence. They also say extortion and other forms of discrimination are rampant.

In February 2008, police rounded up men suspected of being homosexuals after a Senegalese tabloid published photographs of a clandestine gay wedding in a suburb of Dakar. Gays went into hiding or fled to neighboring countries, but they were pushed out of Gambia by the president's threat of decapitation.

A report released this week by Amnesty International says 38 African countries ? about 70 percent of the continent ? criminalize homosexual activity.

In four of those ? Mauritania, northern Nigeria, southern Somalia and Sudan ? the punishment is death.

These laws appear to have broad public support. A June 4 Pew Research Center survey found at least nine of 10 respondents in Senegal, Kenya, Ghana, Uganda and Nigeria believe homosexuality should not be accepted by society.

Sall warned that because of these views, public advocacy on behalf of gay rights could prompt a strong negative reaction. "We need to be careful, because in Africa and in certain Muslim societies, these are subjects that can provoke fundamentalism," he said.

In a December 2011 memorandum, Obama instructed federal agencies to promote gay rights overseas, drawing strong protests from some African officials and many of his African fans. But while experts say the U.S. has forcefully pushed for gay rights behind closed doors, the public positioning has been discreet, with officials often citing concerns about putting local activists in danger.

Prior to this week's Africa trip, Obama's second since becoming president, some advocates had pushed for him to vocally advocate for gay rights, saying the respect he commands in much of Africa could help sway public opinion.

At Thursday's press conference in Dakar, Obama said everyone should be equal under the law regardless of cultural differences. "When it comes to how the state treats people, how the law treats people, I believe that everybody has to be treated equally," he said.

In response, Sall said Senegal was "still not ready" to decriminalize homosexuality. He said the country was "very tolerant" but needed more time to address the issue.

Though Obama's visit was seen as an opportunity to showcase Senegal's stability and history of peaceful democratic transition, the front pages of local newspapers on Friday were dominated by talk of the exchange on homosexuality. The newspaper Liberation, for example, praised Sall for his "courageous" stance and, alongside a photo of Obama and Sall, ran a banner headline that played on Obama's famous campaign slogan: "No, we can't."

Sall said Friday that he was not disappointed that the issue of homosexuality had received so much attention. He said he welcomed the opportunity to contrast his views with Obama's.

"I'm not disappointed, because I'm a democrat and I can understand very well the position of President Obama on this topic," Sall said. "We are friends. We are partners."

Asked Friday if he thought the day might come when gays are accepted in Senegal and throughout Africa, Sall said it was impossible to predict.

"I don't know what will happen in 10 years, because the world changes," he said. "It depends on each culture or each civilization. We have to take time. Because people need time to absorb. It's not something you can have in one day."

Source: http://news.yahoo.com/senegalese-president-defends-anti-gay-law-165212208.html

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Nets, Celtics Trade Nearing Completion, Would Send Garnett, Pierce To Brooklyn: REPORTS

BOSTON (AP) ? The names that Boston Celtics general manager Danny Ainge didn't mention said all anyone needed to know about how he views the team's future.

After trading up three spots to get Gonzaga 7-footer Kelly Olynyk in the NBA draft on Thursday night, Ainge described him as a complementary player who will fit in well with Rajon Rondo, Avery Johnson and Jeff Green.

No mention of the team's biggest stars, Paul Pierce and Kevin Garnett.

"Can't talk about it," Ainge said when the omission was pointed out to him. But asked if there were any untradeable players on the roster, he said, "If Wilt Chamberlain and Kareem Abdul-Jabbar were traded, I guess everybody's tradable."

According to a person with knowledge of the talks, the Celtics and Nets were nearing completion of a deal that would send Garnett and Pierce to Brooklyn in exchange for a package that included three first-round draft picks. The person confirmed the talks to The Associated Press on condition of anonymity because the details were to remain private.

Although the details were not final ? the deal cannot be submitted to the NBA office until next month ? the Celtics were expected to get Gerald Wallace, the expiring contract of Kris Humphries and one other player while sending Jason Terry to Brooklyn.

The deal would complete the breakup of the core that brought Boston its NBA-record 17th championship in 2008. The process began earlier this week when the Celtics traded coach Doc Rivers to the Los Angeles Clippers for a first-round draft pick in 2015.

Boston and Los Angeles had discussed a deal for Garnett, who has a no-trade clause but was expected to waive it to remain with Rivers. But NBA commissioner David Stern said coaches could not be dealt for active players ? as opposed to draft choices ? and nixed any future deals between the Celtics and Clippers.

Instead, the Celtics talked to Brooklyn. The inclusion of Pierce, who is due $15 million next season, and the possibility of swapping a rebuilding team for a contender was expected to encourage Garnett to go along.

"That's what Danny wants to do is rebuild," Rivers said from Clippers draft headquarters. "It's sad to see everybody leave Boston. You just want them to go someplace where they have a chance to win, and they have."

After winning five straight Atlantic Division titles, the Celtics tumbled down the Eastern Conference standings this season, dropping all the way to the No. 7 seed before being eliminated by the New York Knicks in the first round. Ainge has said he wanted to avoid the precipitous fall and long rebuilding process in the 1990s that followed the aging of the original Big Three of Larry Bird, Kevin McHale and Robert Parish ? his teammates on the teams that won it all in 1984 and '86.

The Celtics were no closer to a title ? and in the midst of the longest championship drought in franchise history ? when Ainge arrived in 2003. He rode them into the draft lottery, and when the ping pong balls failed to deliver a star, he traded for Garnett and Ray Allen to join Pierce in a New Big Three that won the NBA title in its first year and returned to the finals two years later.

But the team regressed after losing in the 2010 finals in seven games, and in the first-round loss to the Knicks this spring, Pierce and Garnett looked worn down. That convinced Rivers that his future was elsewhere, and Garnett and Pierce aren't far behind.

Instead, the Celtics begin their rebuilding around Rondo, the one player Ainge said he was not looking to trade. They also have Bradley joining him in the backcourt and Green to fill Pierce's role, and now Olynyk to join Jared Sullinger at power forward after Garnett's gone.

"I think we're in a much better place than we were when I got here 10 years ago," Ainge said. "Our objective is to do it less painfully and to do it with more speed."

Ainge sent the No. 16 pick and two future second-rounders to the Dallas Mavericks to get Olynyk, who was fifth in voting for the Wooden Award. Olynyk averaged 17.8 points and 7.3 rebounds while shooting 63 percent from the field while leading Gonzaga to a 32-3 season.

Ainge said Olynyk was athletic, playing quarterback for his high school football team.

"I don't know too many players who played quarterback in high school as a 7-footer," Ainge said.

The Celtics entered the night without a second-round pick, but they bought the No. 53 overall selection from the Indiana Pacers for cash and used it to pick center Colton Iverson from Colorado State. A person with knowledge of the deal confirmed the transaction Thursday night on condition of anonymity because it was not yet official.

Iverson is a 7-foot, 255-pound center who started his career at Minnesota. Last season, after transferring to Colorado State, he led the team in scoring with 14.2 points and rebounding at 9.8.

___

AP Basketball Writer Brian Mahoney contributed to this story from New York and AP Sports Writer Michael Marot contributed from Indianapolis.

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Source: http://www.huffingtonpost.com/2013/06/28/nets-celtics-trade-garnett-pierce_n_3513602.html

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OFT orders review of payday lenders

By Matt Scuffham and Clare Hutchison

LONDON (Reuters) - The Office of Fair Trading has asked for a review into payday lenders after finding deep-rooted problems in the way the 2 billion pound a year industry treats vulnerable customers.

The lenders, which make loans to be repaid when borrowers get their wages, have grown rapidly in Britain as banks have cut back on short-term credit after the 2008 financial crisis. But they have been attacked by politicians and consumer groups for charging sky-high interest rates and for shoddy treatment of borrowers.

"We have seen evidence of financial loss and personal distress to many people," Clive Maxwell, chief executive of the OFT, said on Thursday.

The OFT said firms were profiting from loans that could not be paid back on time. It found about half of lenders' revenues come from fees charged for customers extending loans. And 20 percent of revenues came from loans which were extended at least four times.

The watchdog said it was difficult for customers to identify and compare the cost of loans from payday lenders and that not all firms complied with relevant laws. It also found that many of the borrowers had poor credit histories and limited access to other forms of credit.

It said lenders were competing primarily on the availability and speed of loans rather than on the price of paying them back.

Payday lenders typically hand out loans of up to 1,000 pounds. The OFT estimated around 8 million are made each year.

Firms such as Wonga, QuickQuid and Lending Stream have flourished as the banks have pulled back. Apart from the payday firms, customers have few alternatives other than to borrow from friends and family or from pawnbrokers such as H&T Group and Albemarle & Bond, which have also thrived.

FULL-BLOWN INQUIRY

In March, the OFT gave Britain's biggest 50 payday lenders 12 weeks to change their business practices or risk losing their licenses after finding evidence of widespread irresponsible lending.

Britain's Competition Commission will now investigate the industry, where annual interest rates on some loans top 5,000 percent. MPs have already called for a cap to be set on the amount of interest charged.

Payday lenders are coming under scrutiny around the world. The U.S. consumer watchdog said in April that the loans were trapping borrowers in a cycle of debt and warned new rules could be on the way for the industry.

The Consumer Finance Association (CFA), which represents the industry in Britain, said the competition inquiry should have been deferred to allow improvements that firms have already made to take effect before they face further judgment.

"No other sector has faced such intense scrutiny in such a short space of time," it said.

Wonga, one the biggest payday lenders in Britain, more than trebled its earnings last year. This month it lifted the annual interest rate on its loans to 5,853 percent.

The inquiry could upset Wonga's plans to launch a stock market flotation next year which analysts say could value the business at up to 1.5 billion pounds. Wonga said on Thursday the commission should review how consumers use and access all forms of short-term credit including overdrafts and credit cards.

Consumer Group Which? said the industry was rife with poor practice.

"People under financial pressure being given high-cost loans in minutes without proper affordability checks is a recipe for disaster," it said.

The Citizens Advice Bureau, a charity that helps people with legal and financial issues, said the focus on speed meant payday loans were being handed out without proper checks.

"The industry is in desperate need of a transformation from predatory firms to a responsible short-term credit market," said Citizens Advice Chief Executive Gillian Guy.

(Editing by Sinead Cruise and Jane Merriman)

Source: http://news.yahoo.com/office-fair-trading-orders-review-payday-lenders-062653169.html

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Sports RoundupOutdoors & Recreation - Tampa Bay Newspapers

Midnight run set for July 3-4
DUNEDIN ??The Kiwanis Morton Plant Mease Midnight Run will be held the evening of July 3 and the morning of July 4 at the Causeway Plaza, 2602 Bayshore Blvd. The Kiwanis Club of Dunedin, Kiwanis Club of Top of the Bay and Morton Plant Mease BayCare Health System sponsor the 10K race, which begins at midnight July 3. The previous 33 Midnight Run events have raised more than $640,000 for the Kiwanis clubs of Dunedin and Top of the Bay community service activities. For more information, call 535-2257.

Basketball team going to nationals
The Team Under Pressure 9th Grade Elite Soldiers, under the Clearwater Basketball Club, are headed to the 10th Grade Nationals and 9th Grade Showcase in July. The Elite Soldiers have won the championship at six of the seven tournaments and are currently seeking sponsors for their trip to the nationals this year.

The team is comprised of top ninth-grade players from Pinellas County representing the following high schools: Clearwater, Countryside, Boca Ciega, Gibbs, Largo, Osceola, St. Pete High and Shorecrest Preparatory.

They are looking for sponsors for their T-shirts and are planning a car wash at the Clearwater Chick-Fil-A on June 29. Anyone interested in sponsoring the team or helping out financially, please contact Carrie Fuoco at 643-7837. Visit www.facebook.com/TeamUnderPressure.

Crabby Bills sponsors charity fish fry
INDIAN ROCKS BEACH ? Crabby Bills, 401 Gulf Blvd., will host a charity fish fry benefiting Gulf Coast Bird Rescue Saturday, June 29, 4 to 7 p.m., at the restaurant. The meal includes fish, slaw and fries for $8.99. Commemorative T-shirts will be available for purchase.

Belleair plans basketball tourney
BELLEAIR ? A three-on-three basketball tournament, called Belleair?s Got Air, will be held Saturday, Aug. 10, 8 a.m. to 8 p.m., at the Dimmitt Community Center. The tournament is modeled after ?Hoop It Up,? a street ball tournament established by the NBA in 1989, and will be run by former Hoop It Up world champion, coach Steve Willis. The tournament is open to people of all ages and abilities and includes 5th, 6th, 7th, and 8th grade brackets. The cost is $80 per team. Individuals are welcome. Call 518-3728.

Vinyasa flow yoga offered
TREASURE ISLAND ? The city of Treasure Island offers vinyasa flow yoga in Treasure Island Park, 106th Avenue and Gulf Boulevard, Mondays from 6:30 to 7:45 p.m. The continual movements, from one pose to another, give participants an added cardiovascular benefit. The routine practice of vinyasa yoga can increase muscle strength, endurance and flexibility, as well as reduce levels of stress. This form of yoga offers a range of health benefits to those who practice it, as it encompasses all areas of mind, body and spirit. For additional information contact instructor Lucy Favaloro at 516-417-1952.

Twilight swimming at Aquatic Center
ST. PETE BEACH ? The St. Pete Beach Aquatic Center, 7701 Boca Ciega Dr., is offering evening pool hours, Monday and Wednesday, 7 to 8:30 p.m., through Aug. 14. For the full schedule of open swim hours visit www.spbrec.com or call 363-9264.

Junior Guard program available
ST. PETE BEACH ? Registration is underway for the Junior Guard program July 15-19, 10 a.m. to 1 p.m., at the St. Pete Beach Aquatic Center, 7701 Boca Ciega Drive. Aquatic staff will lead kids 11 and younger in a variety of aquatics experiences including paddle boarding, beach guarding and American Red Cross Guard Start. The cost is $90 for SPB residents and $100 for nonresidents. For more information visit www.spbrec.com or call 363-9264.

Safe boating class offered
MADEIRA BEACH ? The United States Coast Guard Auxiliary Flotilla 11-3 plans monthly safe boating classes through the end of the year at its headquarters at 299 Boca Ciega Drive. Classes meet the first Saturday of the month from 8 a.m. to 5 p.m. The cost is $40 per person. The next class meets July 6. Other classes will follow on Aug. 3 and Sept. 7. The classes are open to the public and recommended for anyone who owns a boat, a personal watercraft, anyone interested in purchasing a boat or anyone who wants to learn safe boating practices. For more information, call 391-5185 or visit www.a0701103.uscgaux.info.

Coast Guard Auxiliary offers boating courses
DUNEDIN ? ?About Boating Safely,? a course offered by the U.S. Coast Guard Auxiliary Dunedin Flotilla, will be taught in two sessions July 20 and July 21, 9 a.m. to 1 p.m., at the Coast Guard Auxiliary classroom at Dunedin Marina, 51 Main St., second floor.

?About Boating Safely? is designed for both experienced and novice boaters. Some of the topics presented will be boating emergencies, know your boat, getting underway, navigating the waterways, operating your boat safely, and legal requirements.

Register by July 15 to receive course materials prior to the class. The fee is $35, with a $5 discount each for two or more signing up at the same time. Florida Boater Safety Certification Cards are given to individuals who successfully complete the course. For more information, call Kristi Mackey at 736-1191, or email boatsafeaux@gmail.com; Web: www.dunedin-coastguardaux.com.

Added Dunedin events.

Source: http://www.tbnweekly.com/editorial/outdoors/content_articles/062613_out-07.txt

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Be inclusive, Morsi, or you may face a second Egyptian revolution

Will it take a second revolution to complete Egypt?s democratic transition? Anti-government protesters plan to turn out in massive numbers Sunday. President Mohamed Morsi should heed cries for more inclusiveness. Otherwise, he may find himself toppled like Mubarak.

By David A. Super,?Op-ed contributor / June 28, 2013

Egyptian protesters chant slogans against President Mohammed Morsi in Damietta, Egypt, in late June. Thousands of backers of Egypt's Islamist president rallied Friday in Cairo in a show of support ahead of planned opposition protests this weekend demanding his removal. Op-ed contributor David A. Super writes, 'Morsi would be wise to heed the demands of the opposition for a roadmap to national reconciliation.'

Hamada Elrasam/AP

Enlarge

Will it take a second revolution to complete Egypt?s democratic transition, begun more than two years ago? Many Egyptians think so, and they are planning massive demonstrations on Sunday in an attempt to oust President Mohamed Morsi from office.

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Mr. Morsi, an Islamist with roots in the Muslim Brotherhood, was elected last year. Sunday is the anniversary of his inauguration, and his supporters plan counter-demonstrations. Morsi maintains that the ballot box is the way to change leaders, and he?s right ? when elections take place in a democracy.

But Egypt is now under the tight control of a political duopoly of the military and Morsi and his Islamist allies. It has no lawful parliament. Its constitution was created without the input of secular democrats. Opposition activists are under arrest.

Many protesters who started Cairo?s Tahrir Square demonstrations for freedom and rights in 2011 now say their revolution has been hijacked, and they?re right, too.

The increasingly anti-democratic regime reached its nadir this month when it convicted three dozen Egyptian and Western employees of pro-democracy non-profits ? most of the Westerners in abstentia ? for conducting voter education efforts. Sentences ranged from one to five years.

A month earlier, it arrested Ahmed Maher, who co-founded the April 6 youth protest movement, though he was later released pending trial. His communications savvy and raw courage helped pro-democracy demonstrators take and hold Tahrir Square, and ultimately oust dictator Hosni Mubarak.

But after the fall of Mr. Mubarak, who was an Air Force general, the military retained power through a junta of other generals. The generals retained Mubarak?s dreaded security police and their well-documented reliance on torture. The junta arrested bloggers and other activists for non-violent dissent, such as ?insulting? the regime, and gave them long prison sentences in sham military courts.

Curiously, however, the military focused its repression almost entirely on secular democrats: It released Islamists from prison and allowed them to operate freely. The Muslim Brotherhood, in turn, avoided criticizing the military and refused to support calls to hold it accountable for its human rights abuses.

With many of their organizers in jail, the secular democrats were ill-equipped to compete in the country?s first post-Mubarak presidential election last June. The junta, however, took no chances, barring all pro-Western secular democrats from the ballot through its appointed election commission. Morsi was elected because Egyptian voters preferred him to yet another Air Force general. But the generals denied voters plausible alternatives to military or Islamist rule.

Although the Muslim Brotherhood had been a late and halting participant in the revolution, once in power, President Morsi could have risen to the occasion and led all Egyptians into a democratic future. Instead, he entrenched the Brotherhood?s power and cemented its nascent alliance with the military.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/8Di5D56NZVw/Be-inclusive-Morsi-or-you-may-face-a-second-Egyptian-revolution

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'Roam if you want to' - EU lowers mobile fees for summer

By Claire Davenport

BRUSSELS (Reuters) - Checking email or surfing the Web on a mobile phone while travelling in the European Union will be a third cheaper from Monday under roaming cuts enforced by the EU's regulator in time for the summer holiday season.

The European Union has been eager to show its relevance to EU citizens with measures to cut the cost of consumer goods such as flights and roaming fees, with mobile charges a particularly popular step over the past several years.

"The EU has to be relevant to people's lives," the EU's telecoms regulator, Neelie Kroes, said on Thursday as she announced the 36 percent reduction in roaming fees.

Kroes wants to completely eliminate the fees across the 27-nation EU, but there are doubts about whether that can be achieved in the 18 months left in her mandate.

This summer's caps were announced in March last year, but the Commission typically trumpets the lower rates ahead of the summer holidays, when they take effect.

EU regulators have been chipping away at the charges since 2007. The latest cut marks an 80 percent decline since then.

From July 1, the cost of using the Internet while abroad falls to 45 cents per megabyte from 70 cents.

Making calls declines to 24 cents per minute from 29 cents, and receiving calls to 7 cents per minute from 8 cents.

The cost of sending text messages will also go down, to 8 cents from 9 cents. Mobile users don't pay for receiving text messages while travelling in the bloc.

All of costs will fall again on July 1 next year.

"The latest price cuts put more money in your pocket for summer, and are a critical step towards getting rid of these premiums once and for all," Kroes said in a statement.

The cuts will also mean very substantial reductions in charges in Croatia, a popular summer holiday destination. The country is joining the European Union on Monday, raising the total number of member states to 28.

The Commission said mobile Internet use in Croatia will be nearly 15 times cheaper than at present, and text messages and voice calls to another EU country would cost 10 times less from next week.

(Reporting By Claire Davenport; editing by Luke Baker)

Source: http://news.yahoo.com/roam-want-eu-lowers-mobile-fees-summer-135224611.html

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Jezebel 'Black Babies Cost Less': The Racial Realities of Adoption in America | io9 How does spaceti

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Source: http://lauren.kinja.com/jezebel-black-babies-cost-less-the-racial-realities-of-599036790

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Immigration Officer Charged With Taking Egg Rolls As Bribes

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An immigration officer has been indicted on charges that she took cash and egg rolls as bribes from immigrants seeking citizenship and green cards.

Federal prosecutors say 47-year-old Mai Nhu Nguyen was indicted Wednesday on three counts of solicitation of a bribe by a public official.

Read the whole story at ABC

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Source: http://www.huffingtonpost.com/2013/06/27/immigration-officer-egg-rolls_n_3509662.html

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On Gay Marriage In Churches, Stances Vary Among Religions, Clergy, Members

WASHINGTON, DC - JUNE 26: Married couple Michael Knaapen (L) amd John Becker (2nd L) react after hearing the U.S. Supreme Court ruled that the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

WASHINGTON, DC - JUNE 26: Married couple Michael Knaapen (L) amd John Becker (2nd L) kiss after hearing the U.S. Supreme Court ruled that the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

Michael Knaapen, left, and his husband John Becker, right, embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

NEW YORK, NY - JUNE 26: Richelle Spanover (2nd R) wipes her eye after after the Supreme Court ruled key portions of the Defense of Marriage Act (DOMA) unconstitutional, at the Stonewall Inn on June 26, 2013 in the West Village neighborhood of New York City. The Stonewall Inn became historically important in the Lesbian-Gay-Bigender-Transgender community after playing a key role during the Gay-rights movement of the 1960s and 1970s. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Andrew Burton/Getty Images)

NEW YORK, NY - JUNE 26: Virginia Sin (L) and Gretchen Menter smile after the Supreme Court ruled key portions of the Defense of Marriage Act (DOMA) unconstitutional, at the Stonewall Inn on June 26, 2013 in the West Village neighborhood of New York City. The Stonewall Inn became historically important in the Lesbian-Gay-Bigender-Transgender community after playing a key role during the Gay-rights movement of the 1960s and 1970s. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Andrew Burton/Getty Images)

Edith Windsor, center, accompanied by her attorney Robert Kaplan, right, is greeted by Orie Urami, left, as she arrives at the LGBT Center for a news conference, in New York, Wednesday, June 26, 2013. In a major victory for gay rights, the Supreme Court on Wednesday struck down a provision of a federal law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in California. (AP Photo/Richard Drew)

David Boies, an attorney arguing in support of gay marriage, speaks to the media after the U.S. Supreme Court overturned the Defense of Marriage Act (DOMA) and declined to rule on the California law Proposition 8 in Washington, D.C., U.S. on Wednesday, June 26, 2013. A divided U.S. Supreme Court gave a landmark victory to the gay-rights movement, striking down a federal law that denies benefits to same-sex married couples and clearing the way for weddings to resume in California. Photographer: Joshua Roberts/Bloomberg via Getty Images

Chris Roe (L) and Roby Chavez (R) celebrate while holding their soon-to-be adopted children as the US Supreme Court ruling is announced on June 26, 2013. The US Supreme Court struck down The Defense of Marriage Act (DOMA) today, and declared that same-sex couples who are legally married deserve equal rights to the benefits under federal law that go to all other married couples. In another ruling, the Supreme Court cleared the way for same-sex marriages to resume in California as the justices, in a prcedural ruling, turned away the defenders of Proposition 8. AFP PHOTO/Josh Edelson (Photo credit should read Josh Edelson/AFP/Getty Images)

Edith Windsor arrives at the LGBT Center for a news conference, in New York, Wednesday, June 26, 2013. In a major victory for gay rights, the Supreme Court on Wednesday struck down a provision of a federal law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in California. (AP Photo/Richard Drew)

Edith Windsor reacts during a news conference at the LGBT Center, in New York, Wednesday, June 26, 2013. In a major victory for gay rights, the Supreme Court on Wednesday struck down a provision of a federal law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in California. (AP Photo/Richard Drew)

Kris Perry, second from right, kisses her partner Sandy Stier outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for the resumption of same-sex marriage in their home state of California. From left are, plaintiffs Jeff Zarrillo, and his partner Paul Katami, attorney David Boies, plaintiffs Sandy Stier and Kris Perry, and attorney Ted Boutrous. (AP Photo/J. Scott Applewhite)

John Lewis, left, and Stuart Gaffney embrace outside San Francisco's City Hall shortly before the U.S. Supreme Court ruling cleared the way for same-sex marriage in California on Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Noah Berger)

Sandy Stier, center, and her partner Kris Perry, right, plaintiffs in Hollingsworth v. Perry, the California Proposition 8 case, meets with reporters outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court's 5-4 decision that cleared the way for the resumption of same-sex marriage in their home state of California. Gesturing at far left is fellow plaintiff Jeff Zarrillo. (AP Photo/J. Scott Applewhite)

WASHINGTON, DC - JUNE 26: American University students Sharon Burk (L) and Mollie Wagoner (R) embrace after hearing that the U.S. Supreme Court ruled that the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

John Lewis, left, and his partner Stuart Gaffney embrace as they react next to Andrea Shorter after the Supreme Court decision at the office of San Francisco Mayor Ed Lee at City Hall in San Francisco, Wednesday, June 26, 2013. The Supreme Court on Wednesday struck down a provision of a U.S. law denying federal benefits to married gay couples and cleared the way for the resumption of same-sex marriage in the state of California. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Jeff Chiu)

SAN FRANCISCO, CA - JUNE 26: Same-sex couple Jewelle Gomez (R) and Diane Sabin react upon hearing the U.S. Supreme Court's rulings on gay marriage in City Hall June 26, 2013 in San Francisco, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Justin Sullivan/Getty Images)

Gay rights activist Bryce Romero, who works for the Human Rights Campaign, offers an enthusiastic high-five to visitors getting in line to enter the Supreme Court on a day when justices are expected to hand down major rulings on two gay marriage cases that could impact same-sex couples across the country, in Washington, Wednesday, June 26, 2013. (AP Photo/J. Scott Applewhite)

Gay rights activist Bryce Romero, who works for the Human Rights Campaign, offers an enthusiastic high-five to visitors getting in line to enter the Supreme Court on a day when justices are expected to hand down major rulings on two gay marriage cases that could impact same-sex couples across the country, in Washington, Wednesday, June 26, 2013. (AP Photo/J. Scott Applewhite)

WASHINGTON, DC - JUNE 26: Attorney David Boise (C) speaks while flanked by plantiff couples Paul Katami, (L), Jeff Zarillo (2nd L), Sandy Steier (2nd R) and Kris Perry (R) after the U.S. Supreme Court ruled that part of the Defense of Marriage Act (DOMA) is unconstitutional at the Supreme Court, June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Mark Wilson/Getty Images)

Plaintiffs in Hollingsworth v. Perry, the California Proposition 8 case, react on steps of the Supreme Court in Washington, Wednesday, June 26, 2013, after justices cleared the way for the resumption of same-sex marriage in California. From left are, Jeff Zarrillo, and his partner Paul Katami, attorney David Boies, and Sandy Stier and her partner Kris Perry. (AP Photo/J. Scott Applewhite)

Michael Knaapen (L) and his husband John Becker react outside the US Supreme Court in Washington DC on June 26, 2013. The US Supreme Court on Wednesday struck down a controversial federal law that defines marriage as a union between a man and a woman, in a major victory for supporters of same-sex marriage.The Defense of Marriage Act (DOMA) had denied married gay and lesbian couples in the United States the same rights and benefits that straight couples have long taken for granted. AFP PHOTO / MLADEN ANTONOV (Photo credit should read MLADEN ANTONOV/AFP/Getty Images)

WASHINGTON, DC - JUNE 26: Chase Hardin hugs friend Kai Neander on the steps of the Supreme Court after favorable rulings were issued in same sex marriage cases June 26, 2013 in Washington, DC. The high court ruled to strike down DOMA and determined the California's proposition 8 ban on same-sex marriage was not properly before them, declining to overturn the lower court's striking down of the law. (Photo by Win McNamee/Getty Images)

WASHINGTON, DC - JUNE 26: Gay rights supporter Jay Norris, of New York City, holds a U.S. flag outside the U.S. Supreme Court building on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: Martha Acevedo, 25, celebrates the Supreme Court ruling after a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

Ellen Pontac, left, and her wife Shelly Bailes, celebrate in Sacramento, Calif., after the U.S. Supreme Court's ruling on gay marriage in California, Wednesday, June 26, 2013. The 5-4 decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples, like Pontac and Bailes, from receiving tax, health and pension benefits. (AP Photo/Rich Pedroncelli) will now have the same (AP Photo/Rich Pedroncelli)

Attendees at a watch party in Miami celebrate after the U.S. Supreme Court's ruling on gay marriage in California Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Wilfredo Lee)

Julia Tate, left, kisses her wife, Lisa McMillin, as they read results of Supreme Court decisions regarding gay rights on Wednesday, June 26, 2013, in Nashville, Tenn. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. McMillin holds the couple's son, Luke. (AP Photo/Mark Humphrey)

Juan Talavera, right, kisses his partner Jeff Ronci after the announcement of the U.S. Supreme Court's ruling at a watch party in Miami, Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Wilfredo Lee)

Renata Moreira, right, and partner Lori Bilella cheer after the U.S. Supreme Court's ruling on gay marriage in California, at San Francisco's City Hall on Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. The couple plans to marry. (AP Photo/Noah Berger)

WEST HOLLYWOOD, CA - JUNE 26: Erica Ikeda (C), 26, and Jessica Parral (R), 24, react to the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: Brandon Benoit (C) hugs Martha Acevedo (L), 25, and Briana Castaneda, 23, as they celebrate the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: People celebrate in the street after the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

SAN FRANCISCO, CA - JUNE 26: Supporters of same-sex marriage cheer as they learn results of the U.S. Supreme Court's rulings on gay marriage in City Hall June 26, 2013 in San Francisco, United States. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Justin Sullivan/Getty Images)

SAN FRANCISCO, CA - JUNE 26: Same-sex couple Sue Rochman (L) and Robin Romdalvik celebrate upon hearing the U.S. Supreme Court's rulings on gay marriage in City Hall June 26, 2013 in San Francisco, United States. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Justin Sullivan/Getty Images)

Gay rights activists reacts outside the US Supreme Court building in Washington DC on June 26, 2013, after the court ruling on California's Proposition 8, the controversial ballot initiative that defines marriage as between a man and a woman. AFP PHOTO / MLADEN ANTONOV (Photo credit should read MLADEN ANTONOV/AFP/Getty Images)

WEST HOLLYWOOD, CA - JUNE 26: Erica Ikeda (C), 26, and her friends react to the Supreme Court ruling at a watch party at Equality California, a non-profit civil rights organization that advocates for the rights of LGBT people in California, on June 26, 2013 in West Hollywood, California. The high court struck down the Defense of Marriage Act (DOMA) and ruled that supporters of California's ban on gay marriage, Proposition 8, could not defend it before the Supreme Court. (Photo by Kevork Djansezian/Getty Images)

John Lewis, left, gets a kiss from his partner Stuart Gaffney as they embrace after the Supreme Court cleared the way for same-sex marriage in California at the office of San Francisco Mayor Ed Lee at City Hall in San Francisco, Wednesday, June 26, 2013. The justices issued two 5-4 rulings in their final session of the term. One decision wiped away part of a federal anti-gay marriage law that has kept legally married same-sex couples from receiving tax, health and pension benefits. The other was a technical legal ruling that said nothing at all about same-sex marriage, but left in place a trial court's declaration that California's Proposition 8 is unconstitutional. (AP Photo/Jeff Chiu)

WASHINGTON, DC - JUNE 26: Plaintiff couple Sandy Stier (C) and Kris Perry (L) arrive for their Proposition 8 case before the U.S. Supreme Court on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

WASHINGTON, DC - JUNE 26: Gay rights supporters Brian Sprague (L) and Charlie Ferrusi, from Albany, New York, hold a Human Rights flag outside U.S. Supreme Court building on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

WASHINGTON, DC - JUNE 26: Gay rights supporter Vin Testa waves a rainbow flag outside the U.S. Supreme Court building on June 26, 2013 in Washington, DC. The high court is expected to rule on the DOMA and Prop 8 gay marriage cases. (Photo by Win McNamee/Getty Images)

Gay rights activists gather outside the US Supreme Court building in Washington, DC on June 26, 2013. The US Supreme Court on Wednesday struck down a controversial federal law that defines marriage as a union between a man and a woman, in a major victory for supporters of same-sex marriage.The Defense of Marriage Act (DOMA) had denied married gay and lesbian couples in the United States the same rights and benefits that straight couples have long taken for granted. AFP PHOTO / MLADEN ANTONOV (Photo credit should read MLADEN ANTONOV/AFP/Getty Images)

American University students Sharon Burk, left, and Molly Wagner, embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

Arriving at the Supreme Court in Washington, Wednesday, June 26, 2013, on a final day for decisions in two gay marriage cases are plaintiffs in the California Proposition 8 case, from left, Paul Katami, his partner Jeff Zarrillo, and Sandy Stier and her partner Kris Perry. (AP Photo/J. Scott Applewhite)

Michael Knaapen, left, and his husband John Becker, right, embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013 after the court struck down a federal provision denying benefits to legally married gay couples. (AP Photo/Charles Dharapak)

American University students Sharon Burk, left, and Molly Wagner participate in a rally for rights for gay couples in front of the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

Supporters of gay marriage embrace outside the Supreme Court in Washington, Wednesday, June 26, 2013, after the court cleared the way for same-sex marriage in California by holding that defenders of California's gay marriage ban did not have the right to appeal lower court rulings striking down the ban. (AP Photo/Charles Dharapak)

Sen. Richard Blumenthal (D-Conn.) spotted in the crowd during the SCOTUS decisions on June 26

Source: http://www.huffingtonpost.com/2013/06/26/gay-marriage-church-religion-prop-8-doma_n_3469191.html

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Gay-Marriage Ruling Sparks Crazy Dancing And Body Paint: Watch Here!

MTV News rounds up the Web buzz around the SCOTUS decision.
By Emily Blake and Emilee Lindner

Source: http://www.mtv.com/news/articles/1709658/gay-marriage-ruling-celebration.jhtml

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USC research IDs potential treatment for deadly, HIV-related blood cancer

Public release date: 25-Jun-2013
[ | E-mail | Share ]

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences

First report to show BRD4 inhibitors can fight off primary effusion lymphoma

LOS ANGELES Researchers at the USC Norris Comprehensive Cancer Center have discovered a promising new way to treat a rare and aggressive blood cancer most commonly found in people infected with HIV.

The USC team shows that a class of drugs called BET bromodomain inhibitors effectively targets primary effusion lymphoma (PEL), a type of cancer for which those drugs were not expected to be effective.

"It's a reversal of the paradigm," said Preet Chaudhary, MD, PhD, chief of the Nohl Division of Hematology and Blood Diseases at the Keck School of Medicine of USC and principal investigator of the study. "Our results suggest that this new class of drug may be an effective treatment for a wider range of cancers than previously thought."

PEL is caused by infection with Kaposi's sarcoma-associated herpes virus, the most common cause of cancer among patients with AIDS. The prognosis for PEL is poor, with a median survival of three to six months. Thus, there is a critical need for new therapies for the disease.

Chaudhary and his colleagues show that inhibitors targeting the BRD4 protein blocked growth of PEL cells in a test tube and in a mouse model. The results were surprising because BET inhibitors were thought to be only effective against cancers linked to an overexpression of the Myc gene.

"We actually found that cancers that overexpress Myc are not as responsive to BRD4 inhibitors. PEL is more responsive," Chaudhary said.

Cancers like multiple myeloma and Burkitt's lymphoma overexpress the Myc gene and have been shown to respond to BRD4 inhibitors. In PEL, the Myc gene is moderately expressed and there is no chromosomal translocation as is seen in multiple myeloma or Burkitt's.

More research is needed to create compounds ready for testing in people. Once those drugs are ready for clinical trial, data from this study suggest that they may treat a wide range of cancers. Chaudhary anticipates testing them alone and in combination with other drugs.

###

The study, "Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors," appears in Oncogene, a peer-reviewed scientific journal from the Nature Publishing Group.

Bhairavi Tolani, PhD, a 2013 graduate of the Keck School of Medicine, is the study's first author. Co-authors include Ramakrishnan Gopalakrishan, PhD; Vasu Punj, PhD; and Hittu Matta, PhD, all of the hematology division at Keck. Their work was supported by grants from the National Institutes of Health (5R01CA139119, 5R01DE019811, P30CA014089) and STOP Cancer Foundation.

Article cited:

Tolani, B., Gopalakrishnan, R., Punj, V., Matta, H., & Chaudhary, P.M. (2013). Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. Published online June 24, 2013; doi:10.1038/onc.2013.242

ABOUT USC NORRIS COMPREHENSIVE CANCER CENTER

USC Norris Comprehensive Cancer Center has been leading the fight to make cancer a disease of the past. As one of the eight original comprehensive cancer centers in the United States, its mission is to treat and prevent cancer by advancing and integrating education, research, and personalized patient care. For 40 years, USC Norris has been revolutionizing cancer research with innovative surgical techniques and novel cancer treatments. The cancer center's breakthroughs and discoveries in the field of epigenetics have led the way to a greater understanding of the underlying causes of cancer and new methods of prevention, detection, and treatment. With a multidisciplinary team of more than 250 dedicated scientists and physicians, USC Norris Comprehensive Cancer Center offers patients hope in the battle against cancer.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 25-Jun-2013
[ | E-mail | Share ]

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences

First report to show BRD4 inhibitors can fight off primary effusion lymphoma

LOS ANGELES Researchers at the USC Norris Comprehensive Cancer Center have discovered a promising new way to treat a rare and aggressive blood cancer most commonly found in people infected with HIV.

The USC team shows that a class of drugs called BET bromodomain inhibitors effectively targets primary effusion lymphoma (PEL), a type of cancer for which those drugs were not expected to be effective.

"It's a reversal of the paradigm," said Preet Chaudhary, MD, PhD, chief of the Nohl Division of Hematology and Blood Diseases at the Keck School of Medicine of USC and principal investigator of the study. "Our results suggest that this new class of drug may be an effective treatment for a wider range of cancers than previously thought."

PEL is caused by infection with Kaposi's sarcoma-associated herpes virus, the most common cause of cancer among patients with AIDS. The prognosis for PEL is poor, with a median survival of three to six months. Thus, there is a critical need for new therapies for the disease.

Chaudhary and his colleagues show that inhibitors targeting the BRD4 protein blocked growth of PEL cells in a test tube and in a mouse model. The results were surprising because BET inhibitors were thought to be only effective against cancers linked to an overexpression of the Myc gene.

"We actually found that cancers that overexpress Myc are not as responsive to BRD4 inhibitors. PEL is more responsive," Chaudhary said.

Cancers like multiple myeloma and Burkitt's lymphoma overexpress the Myc gene and have been shown to respond to BRD4 inhibitors. In PEL, the Myc gene is moderately expressed and there is no chromosomal translocation as is seen in multiple myeloma or Burkitt's.

More research is needed to create compounds ready for testing in people. Once those drugs are ready for clinical trial, data from this study suggest that they may treat a wide range of cancers. Chaudhary anticipates testing them alone and in combination with other drugs.

###

The study, "Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors," appears in Oncogene, a peer-reviewed scientific journal from the Nature Publishing Group.

Bhairavi Tolani, PhD, a 2013 graduate of the Keck School of Medicine, is the study's first author. Co-authors include Ramakrishnan Gopalakrishan, PhD; Vasu Punj, PhD; and Hittu Matta, PhD, all of the hematology division at Keck. Their work was supported by grants from the National Institutes of Health (5R01CA139119, 5R01DE019811, P30CA014089) and STOP Cancer Foundation.

Article cited:

Tolani, B., Gopalakrishnan, R., Punj, V., Matta, H., & Chaudhary, P.M. (2013). Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. Published online June 24, 2013; doi:10.1038/onc.2013.242

ABOUT USC NORRIS COMPREHENSIVE CANCER CENTER

USC Norris Comprehensive Cancer Center has been leading the fight to make cancer a disease of the past. As one of the eight original comprehensive cancer centers in the United States, its mission is to treat and prevent cancer by advancing and integrating education, research, and personalized patient care. For 40 years, USC Norris has been revolutionizing cancer research with innovative surgical techniques and novel cancer treatments. The cancer center's breakthroughs and discoveries in the field of epigenetics have led the way to a greater understanding of the underlying causes of cancer and new methods of prevention, detection, and treatment. With a multidisciplinary team of more than 250 dedicated scientists and physicians, USC Norris Comprehensive Cancer Center offers patients hope in the battle against cancer.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-06/uosc-uri062513.php

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